Acute Cardiopulmonary Decompensation and Complement Activation During Hemodialysis

Brief Reports1 May 1979Acute Cardiopulmonary Decompensation and Complement Activation During HemodialysisJOHN W. AGAR, M.D., JOE D. HULL, M.D., MELVIN KAPLAN, M.D., PETER G. PLETKA, M.D.JOHN W. AGAR, M.D., JOE D. HULL, M.D., MELVIN KAPLAN, M.D., PETER G. PLETKA, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-5-792 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCardiopulmonary decompensation associated with leukopenia during the course of hemodialysis has been described (1). That a cellophane dialysis membrane-activated complement mechanism may have been responsible for pulmonary sequestration of leukocytes resulting in pulmonary dysfunction has been suggested (2).We report a case of severe pulmonary decompensation occurring in nine consecutive hemodialyses, which appeared to be associated with complement activation and did not respond to and could not be prevented by intravenous administration of hydrocortisone and antihistamine.A 13-year-old boy sustained a severe crush injury to the left thigh resulting in acute myoglobinuric oliguric renal failure and severe hyperkalemia requiring early...References1. CRADDOCK P, FEHR J, BRIGHAM K, KRONENBERG R, and JACOB H: Complement and leukocyte-mediated pulmonary dysfunction in hemodialysis. N Engl J Med 296:769-774, 1977 CrossrefMedlineGoogle Scholar2. CRADDOCK P, FEHR J, DALMASSO A, BRIGHAM K, and JACOB H: Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. J Clin Invest 59:879-888, 1977 CrossrefMedlineGoogle Scholar3. KAPLOW L and GOFFINET J: Profound neutropenia during the early phase of hemodialysis. JAMA 203:1135-1137, 1968 CrossrefMedlineGoogle Scholar4. MACGREGOR R: Granulocyte adherence changes induced by hemodialysis, endotoxin, epinephrine, and glucocorticoids. Ann Intern Med 86:35-39, 1977 LinkGoogle Scholar5. GRANT J, DUPREE E, GOLDMAN A, SCHULTZ D, and JACKSON A: Complement-mediated release of histamine from human leukocytes. J Immunol 114:1101-1106, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN W. AGAR, M.D.; JOE D. HULL, M.D.; MELVIN KAPLAN, M.D.; PETER G. PLETKA, M.D.Affiliations: University of Massachusetts Medical Center Worcester, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDialyzer Structure and Membrane BiocompatibilityMembrane BiocompatibilityMembrane BiocompatibilityCardiac anaphylaxis. Complement activation as an amplification system.Reprocessing of Hemodialyzers: A Critical AppraisalAnalysis of the complement C3 fragments associated with hemodialysis membranesDialysis-Associated Hypoxemia: Insights into Pathophysiology and PreventionClinical Significance of Blood-Device Interaction in Hemodialysis. A ReviewNeutrophil and Monocyte Alterations in Chronic Dialysis PatientsThe role of thromboxane in cuprophan–induced pulmonary hypertensionEffect of Dialyzer Reprocessing Methods on Complement Activation and Hemodialyzer-Related SymptomsAcute Anaphylactoid Reactions During Hemodialysis in FranceCardiopulmonary effects of cuprophane–activated plasma in the swinePulmonary Gas Exchange During Hemodialysis and Peritoneal Dialysis: Interaction Between Respiration and MetabolismSevere Reactions During HemodialysisComplement Activation and Hypersensitivity Reactions to Dialysis MembranesMechanisms of Acute Allergic ReactionsBlood-Dialyzer Interactions: Hemodynamic Manifestations in an Animal ModelHaemodynamic Manifestations Of Blood-dialyser Interactions And Their Modification In An Animal ModelFirst-use Syndrome with Cuprammonium Cellulose DialyzersThe influence of haemoperfusion on white cells, immunoglobulin concentrations and the complementsystem in the treatment of intoxicationsSevere Reactions to Cuprophan Capillary DialyzersDialysisHost Defenses and Immunologic Alterations Associated with Chronic HemodialysisSIMEON E. GOLDBLUM, M.D., WILLIAM P. REED, M.D. 1 May 1979Volume 90, Issue 5Page: 792-793KeywordsAntihistaminesComplement activationMedical dialysisRenal failure ePublished: 1 December 2008 Issue Published: 1 May 1979 PDF downloadLoading ...