Key result
Early statin therapy within 48 hours of admission was associated with a reduced risk of atrial fibrillation in patients with acute myocardial infarction (3.9% vs 7.0%; OR 0.64; 95% CI 0.45-0.92).
Why the study?
Does early statin therapy prevent the development of atrial fibrillation in patients with acute myocardial infarction?
Population
3,396 patients with sinus rhythm developing acute myocardial infarction enrolled in the French registry of…
Comparison
Early statin therapy, including conventional… vs No early statin therapy (≤48 hours of admission).
Design
Cohort
Follow-up
Acute stage of myocardial infarction
Authors
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May support early statin use to lower post-MI AF risk; hypothesis-generating and requires RCTs before practice change.
Cohort (n=3,396)
Yes
Does early statin therapy prevent the development of atrial fibrillation in patients with acute myocardial infarction?
Odds Ratio: 0.64 (95% CI 0.45–0.92)
Absolute Event Rate: 3.9% vs 7%
p-value: p=0.017
Early statin therapy within 48 hours of admission for acute myocardial infarction is associated with a significantly reduced risk of developing atrial fibrillation.
Fauchier et al. (2010) conducted a cohort in Acute myocardial infarction (n=3,396). Early statin therapy (≤48 h of admission) vs. No early statin therapy was evaluated on Development of atrial fibrillation (OR 0.64, 95% CI 0.45 to 0.92, p=0.017). Early statin therapy within 48 hours of admission was associated with a reduced risk of atrial fibrillation in patients with acute myocardial infarction (3.9% vs 7.0%; OR 0.64; 95% CI 0.45-0.92).
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