Why the study?
Does physostigmine administration improve symptoms in patients with central anticholinergic syndrome?
Does physostigmine administration improve symptoms in patients with central anticholinergic syndrome?
Central anticholinergic syndrome should be considered in cases of abnormal mental recovery after anaesthesia or sedation, as delayed diagnosis can lead to dangerous complications.
Prompts physostigmine consideration in suspected central anticholinergic syndrome; hypothesis-generating and requires prospective trials.
This report describes two cases of central anticholinergic syndrome, the first after general anaesthesia and the other during a prolonged stay in the intensive care unit. The symptoms in both patients resolved soon after physostigmine administration. There was a delay in the diagnosis of central anticholinergic syndrome, which resulted in acute lung injury and unanticipated intensive care unit admission. It is suggested that in cases of abnormal mental recovery after anaesthesia or sedation, the diagnosis of central anticholinergic syndrome should be considered.
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Katsanoulas et al. (1999) studied this question.
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