Key result
Covariate-based linkage analysis identified a potential genetic locus on chromosome 15 influencing the development of seizures in individuals with systemic lupus erythematosus.
Observational
Covariate-based linkage analysis can increase the power to detect genetic loci in complex diseases with genetic heterogeneity, such as identifying a locus for seizures in SLE.
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Should not alter seizure risk assessment in SLE; leaves open independent replication of the chromosome 15 locus.
Complex genetic disease is inherently difficult to study due to an imperfect relationship between genotype and phenotype. One important reason for this imperfect relationship is genetic heterogeneity, the occurrence of different genetic factors underlying the same clinical syndrome. One method of addressing genetic heterogeneity is covariate-based linkage analysis, which allows the use of additional phenotypic features to define genetically distinct subsets of patients. Systemic lupus erythematosus (SLE) is one example of a complex genetic disease affecting multiple organ systems including the central nervous system. We report here the use of covariate-based linkage analysis to detect a potential genetic locus on chromosome 15 influencing the development of seizures in individuals with SLE. The use of covariates increases the power to detect linkage in the presence of genetic heterogeneity.
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Bautista et al. (2007) conducted an observational in Systemic lupus erythematosus (SLE). Genetic locus on chromosome 15 was evaluated on Development of seizures. Covariate-based linkage analysis identified a potential genetic locus on chromosome 15 influencing the development of seizures in individuals with systemic lupus erythematosus.
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