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In search for a better way to monitor the hybridization and denaturation of DNA onto a diamond based sensor, precise knowledge about the conditions of the immediate surroundings is very critical. One of the factors that have a great influence on the stability of the measurements is the temperature of the liquid environment in which these measurements take place. With this as a focal point, the design of a precise temperature regulator based on a boron doped diamond thin film is a key factor to achieve accurate measurements on a standalone basis. In this work temperature control is achieved making use of a thin boron doped nanocrystalline diamond (B‐NCD) film, which, in combination with a proportional‐integral‐derivative‐control (PID), is able to maintain a stable temperature with an accuracy better than 0.1 °C. By letting the B‐NCD‐layer act as a resistor together with the appropriate control it is possible to maintain a stable temperature in a range going from room temperature till 70 °C, with an accuracy exceeding a temperature variation 0.1 °C. The first prototype makes use of a reference temperature sensor, to verify the accuracy of the results.
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Clukers et al. (2010) studied this question.
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