Key result
Direct intraembryonic injection of Rat Virus into fetal hamsters on the 12th or 13th day of gestation produced fetal death at or soon after parturition, whereas intravenous injection caused no apparent ill-effect.
Rat Virus causes fetal death when injected intraembryonically in hamsters, but has no apparent ill-effect when injected intravenously.
Route-specific fetal lethality in hamster model; leaves open relevance to human vertical transmission.
RV injected into pregnant hamsters during early stages of gestation has a predilection for tissues associated with the gravid uterus and embryo, reaching significantly higher titers in 4 days as compared to control tissues, then decreasing as maternal antibody levels begin to rise. 2. Direct intraembryonic injection of RV into fetal hamsters on the 12th or 13th day of gestation produces fetal death at, or soon after, parturition. 3. Following intravenous injection, RV causes no apparent ill-effect on either the maternal or embryonic tissues.
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Ferm et al. (1963) studied Rat Virus (RV) Infection. Rat Virus (RV) injection vs. Control tissues / Intravenous injection was evaluated on Viral titers and fetal death. Direct intraembryonic injection of Rat Virus into fetal hamsters on the 12th or 13th day of gestation produced fetal death at or soon after parturition, whereas intravenous injection caused no apparent ill-effect.
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