Key result
Intravenous liposomal amphotericin B and oral flucytosine, along with shunt removal, led to the resolution of Candida auris ventriculitis without complications in a 41-year-old man.
Why the study?
Candida auris is an emerging fungal pathogen with high resistance rates, and patients with invasive medical devices are at increased risk of infection.
Case Report (n=1)
This case report demonstrates the successful treatment of highly resistant Candida auris ventriculitis using a combination of intravenous liposomal amphotericin B, oral flucytosine, and device removal.
Answers are grounded in this paper and cite their sources.
May guide salvage therapy in C. auris CNS infections; hypothesis-generating and requires prospective validation before broader adoption.
Candida auris is a rapidly emerging fungal pathogen associated with high resistance rates, particularly in healthcare settings. It most commonly affects patients with severe underlying medical conditions and requiring complex medical care. Patients with invasive medical devices tend to be at increased risk for getting C auris and developing infection. This article presents a case of C auris ventriculitis successfully treated with intravenous liposomal amphotericin B and oral flucytosine. A 41-year-old man with multiple comorbidities, including recent placement of a ventriculoperitoneal shunt, presented with suspected sepsis. Candida auris was isolated from cerebrospinal fluid cultures. Antifungal therapy along with removal of the shunt led to resolution of infection without complications. This case highlights the challenges posed by C auris infections and underscores the importance of appropriate treatment strategies.
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Nayoung Kang (2024) conducted a case report in Candida auris ventriculitis (n=1). Intravenous liposomal amphotericin B and oral flucytosine was evaluated on Resolution of infection without complications. Intravenous liposomal amphotericin B and oral flucytosine, along with shunt removal, led to the resolution of Candida auris ventriculitis without complications in a 41-year-old man.
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