Ketoconazole was used to treat an indolent case of cryptococcal meningitis that had not completely responded to a course of standard therapy with amphotericin B and flucytosine. Despite treatment with 600 mg/day of ketoconazole for seven months and adequate serum and CSF concentrations, the patient suffered a relapse while still receiving the drug. After the relapse, the condition responded to a higher-than-standard dose course of amphotericin B and flucytosine. (JAMA1982;247:3349-3351)
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John R. Perfect (1982) studied this question.
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