Effects of Natural Chalcone–Tannin Hybrids Protecting Mesenchymal Stem Cells against ROS-mediated Oxidative Damage and Indexes for Antioxidant Mechanisms

As antioxidants and potential beneficial agents in cell transplantation, natural chalcone–tannin hybrids can protect mesenchymal stem cells against ROS-mediated damage. In their antioxidant abilities, galloyl moiety, 4-OH, and 2′-OH present antioxidant indexes of 0.58:0.13:0.29. The galloyl moiety enhances antioxidant levels of chalcone–tannin hybrids. Their antioxidant mechanisms may include Fe2+-chelating and direct radical scavenging, which comprises at least one electron transfer (ET). The Fe2+-chelating and ET may mainly occur in the galloyl moiety, while 4-OH without H-bonding interference prefers to donate H atom. Two natural chalcone–tannin hybrids as antioxidants, protect mesenchymal stem cells against ROS-mediated damage. In their antioxidant abilities, galloyl moiety, 4-OH, and 2′-OH present antioxidant indexes at 0.58:0.13:0.29. Galloyl moiety enhances their antioxidant levels. Antioxidant mechanisms may include Fe2+-chelating and direct radical-scavenging. The Fe2+-chelating and electron-transfer mainly occurs in galloyl; while 4-OH prefers to donate H atom.