Effect of Brazilin on Plasma Lipid Levels in Spontaneously Hypertensive Rats

The levels of plasma lipid and lipoprotein in spontaneous hypertensive male rats (SHR) fed on normal chow diet, SHR fed on normal chow diet containing 2% cholesterol plus 10% olive oil and SHR fed on the same fat rich diet with the administration (100 mg/kg, orally) of brazilin, 7,11b‐Dihydrobenz [b] indeno 1,2‐d) pyran‐3,6a,9,10 [6H]‐tetrol, were determined to elucidate the effects of brazilin on the improvement of abnormalities in plasma lipid and lipoprotein concentrations of essential hypertensive rats. Plasma levels of total cholesterol, triglyceride and high density lipoprotein‐cholesterol of SHR were significantly changed toward normal physiological values by the treatment with brazilin.