The present investigations were conducted to ascertain the influence of Pb2+ and Cd2+ both individually and in combination on selected enzymes of tricarboxylic acid (TCA) cycle. All the enzymes of TCA cycle examined (α-ketoglutarate dehydrogenase, isocitrate dehydrogenase, succinate dehydrogenase, malate dehydrogenase) were affected deleteriously by Pb2+ as well as Cd2+ and these metals in combination gave more or less an additive effect.
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Bansal et al. (2002) studied this question.
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