Recombinational analysis of the viablet-haplotypet38

SUMMARY A viablet-haplotype,t38, has been shown to distort linkage relations in theT−tfregion of mouse chromosome 17. Separate experiments were done with two different interstitial markers,Lowandqk, which map respectively about 5 and 4 centimorgans (cM) from the locus ofTin femaleT+tf/ + (Loworqk)+ heterozygotes. In females that carriedt38, however (i.e.t38+ + / +Low tfort38+ + / +qk tf), there was virtually no recombination betweent38and either interstitial marker, although thet38−tfdistance was normal. These observations suggest thatt38suppresses recombination in the lefthand part of that region and strongly enhances it further to the right.