Key result
Ovariectomy in young goats increased intramuscular fat (3.37% vs 1.62%; P=0.009) and altered fatty acid composition by modifying lipid-metabolic gene expression.
Why the study?
Does ovariectomy alter fatty acid composition and lipid-metabolic gene expression in the muscles of young goats?
Does ovariectomy alter fatty acid composition and lipid-metabolic gene expression in the muscles of young goats?
Ovariectomy in young goats alters muscle fatty acid composition, potentially by modifying the expression of lipid-metabolic genes.
Ovariectomy increases growth and intramuscular fat in goats via gene changes; leaves open translational relevance to mammalian metabolism.
This study investigated the fatty acid composition and mRNA levels of acetyl-coenzyme A carboxylase (ACC), fatty acid synthase (FAS), hormone-sensitive lipase (HSL) and lipoprotein lipase (LPL) genes in the Longissimus dorsi muscle (LD) and Biceps femoris muscle (BF) of nine ovariectomised young goats, 50 days after ovariectomy at 5 months of age, relative to nine Control goats. Ovariectomy resulted in faster growth rates (130 vs 110 g/days; P = 0.027), more intramuscular fat (3.37% vs 1.62%; P = 0.009) and heavier final weights (28.3 vs 26.6 kg; P = 0.035). The total saturated fatty acid, C15:0 in the LD and C6:0, C11:0, C12:0, C15:0 and C21:0 in the BF were lower in ovariectomised goats than that in the Control goats (P < 0.05). Ovariectomy increased the total monounsaturated fatty acids in the LD (P < 0.05) and BF (P < 0.01). In the BF, the total polyunsaturated fatty acids and C18:2 of ovariectomised goats were lower than those of the Control goats (P < 0.05), and the C20:2 content significantly decreased in the LD (P < 0.05). The LD of the ovariectomised goats expressed significantly higher FAS but lower HSL mRNA levels than those of Control goats (P < 0.01). Significantly higher ACC, FAS and LPL and lower HSL mRNA levels were observed in the BF of the ovariectomised goats than in the BF of Controls (P < 0.05). These data suggest that ovariectomy affects fatty acid composition potentially by altering the expression of lipid-metabolic genes in the muscles of young goats.
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Zhang et al. (2015) studied this question. Ovariectomy vs. Control was evaluated on Intramuscular fat (p=0.009). Ovariectomy in young goats increased intramuscular fat (3.37% vs 1.62%; P=0.009) and altered fatty acid composition by modifying lipid-metabolic gene expression.
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