A Perspective on the Stereodefined N,O-Acetals: Synthesis and Potential Applications

Developing chemical reactions that rapidly introduce molecular diversity in a controlled manner represents a prime goal in synthetic organic chemistry. In this regard, our recent studies on the asymmetric synthesis and utilization of stereodefined N , O -acetal opens up a conceptually new methodology. The synthesis of labile N , O -acetals was accomplished by highly efficient and chemoselective Pd-catalyzed asymmetric hydroamination of alkoxyallenes. Furthermore, the utility of the stereodefined N , O -acetals as a stereodiversity-generating element was established by the gold-catalyzed cycloisomerization. In addition to these results, new aspects of the N , O -acetals as diversity-generating elements are also discussed.