A highly E-selective ring-closing metathesis is the key to building the macrocyclic salicylate core of (+)-salicylihalamide A (1). The synthesis results in a reassignment of the absolute configuration of natural (−)-salicylihalamide A (2), a structurally unprecedented antitumor metabolite with a potentially novel mode of action.
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Wu et al. (2000) studied this question.
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