Key result
Pregnant women with chronic venous disease exhibited altered placental lipidomic profiles, including elevated lysophosphatidylcholines and diminished omega 9 non-esterified fatty acids compared to healthy controls.
Why the study?
Chronic venous disease is prevalent and poses increased risk during pregnancy with known structural placental changes, motivating metabolomic profiling to understand these placental pathologies.
Are there differences in the metabolomic profiles of chorionic villi in pregnant women with versus without chronic venous disease?
Case-Control (n=12)
No
Are there differences in the metabolomic profiles of chorionic villi in pregnant women with versus without chronic venous disease?
Chronic venous disease during pregnancy is associated with altered lipidomic and metabolomic profiles in placental chorionic villi, suggesting a potential role in its pathogenesis.
May warrant placental monitoring in chronic venous disease pregnancies; leaves open causal links to outcomes pending prospective studies.
Background: Chronic venous disease (CVD) is a prevalent lower limb venous pathology that especially affects women, who also show an increased risk of this disease during pregnancy.Studies have shown significant structural changes in the placentas of women with CVD and several markers of tissue damage have been also described. Patients and Methods:To try to understand the different placental pathologies, research efforts have focused on examining metabolomic profiles as indicators of the repercussions of these vascular disorders.This study examines changes produced in the metabolomic profiles of chorionic villi in the placentas of women with CVD.In a study population of 12 pregnant women, 6 with and 6 without CVD, we compared through mass spectroscopy coupled to ultra-high performance liquid chromatography (UHPLC-MS), 240 metabolites in chorionic villus samples.Results: This study is the first to detect in the placental villi of pregnant women with CVD, modifications in lysophosphatidylcholines and amino acids along with diminished levels of other lipids such as triglycerides, sphingomyelins, and non-esterified omega 9 fatty acids, suggesting a role of these abnormalities in the pathogenesis of CVD.Conclusions: Our findings are a starting point for future studies designed to examine the impacts of CVD on maternal and fetal well-being.
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Ortega et al. (2020) conducted a case-control in Chronic venous disease during pregnancy (n=12). Chronic venous disease vs. Healthy pregnant women without chronic venous disease was evaluated on Lipidomic and metabolomic profile of chorionic villi. Pregnant women with chronic venous disease exhibited altered placental lipidomic profiles, including elevated lysophosphatidylcholines and diminished omega 9 non-esterified fatty acids compared to healthy controls.
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