Key result
Platelet counts in male patients on long-term anticoagulant therapy with phenindione alone appeared to show seasonal fluctuation over a 14-month period.
Observational
Platelet counts in male patients on long-term phenindione therapy may exhibit seasonal fluctuations.
May warrant seasonal platelet monitoring in male phenindione patients; hypothesis-generating and should not yet change practice.
A mono‐amine oxidase inhibitor (Nialamide) has been shown to reduce the extent of induced thrombosis in experimental animals, and to enhance the anticoagulant effects of both phenindione and warfarin (Shimamoto, Yamazaki, Tsuchihashi and Sunaga, 1961; Shimamoto, Ishioka and Jujita, 1962), but these effects were apparent for only a few hours after administration of the drug. Maschouf, Robinson and LeBeau (1964) were able to demonstrate a rapid reduction in platelet adhesiveness in human subjects following a single dose of 75–100 mg., but long‐term treatment of patients with Nialamide alone in doses of 75–200 mg. daily, or in doses of 75 mg. daily in combination with phenindione, had no obvious effect on the total platelet count, or on the adhesive or non‐adhesive platelet count (Eastham, 1964b; Maschouf et al., 1964). Control platelet counts taken from male patients on long‐term anticoagulant therapy with phenindione alone appeared to show some seasonal fluctuation. These results have therefore been examined in detail over a 14‐month period.
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Eastham et al. (1966) conducted an observational in Long-term anticoagulant therapy. Season was evaluated on Platelet counts (total, adhesive, and non-adhesive). Platelet counts in male patients on long-term anticoagulant therapy with phenindione alone appeared to show seasonal fluctuation over a 14-month period.
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