Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies

// Alberto Ocana 1 and Atanasio Pandiella 2 1 Unidad de Investigación Traslacional, Hospital Universitario de Albacete, Universidad de Castilla La Mancha, Albacete, Spain 2 Instituto de Biología Molecular y Celular del Cáncer and CIBERONC. CSIC-Universidad de Salamanca, Salamanca, Spain Correspondence to: Alberto Ocana, email: // Keywords : triple negative breast cancer, breast cancer, kinases, novel therapies Received : December 12, 2016 Accepted : January 11, 2017 Published : January 18, 2017 Abstract Triple negative breast cancer (TNBC) is still an incurable disease despite the great scientific effort performed during the last years. The huge heterogeneity of this disease has motivated the evaluation of a great number of therapies against different molecular alterations. In this article, we review the biological bases of this entity and how the known molecular evidence supports the current preclinical and clinical development of new therapies. Special attention will be given to ongoing clinical studies and potential options for future drug combinations.