Key result
Chemotherapy and molecular targeted therapy in cancer patients are associated with vascular toxicities such as thromboembolic events and hemorrhage, which require imaging for early detection.
Radiologists must maintain a high index of suspicion and awareness of modern-day drug toxicities to early diagnose and manage vascular complications of cancer therapies.
OBJECTIVE: Venous and arterial thromboembolic events and rarely hemorrhage are complications of chemotherapy and, more recently, of molecular targeted therapy in patients with solid and hematologic malignancies. This article will use a drug-based approach to illustrate, with examples, vessel damage and end-organ damage induced by molecular targeted therapy and chemotherapy in cancer patients and will provide a clinical perspective. CONCLUSION: Imaging plays a key role in the detection of complications of cancer therapies. A high index of suspicion and an awareness of modern-day drug toxicities are key to the early diagnosis and management of these complications.
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Rohatgi et al. (2014) conducted a review in Solid and hematologic malignancies. Chemotherapy and molecular targeted therapy was evaluated on Venous and arterial thromboembolic events and hemorrhage. Chemotherapy and molecular targeted therapy in cancer patients are associated with vascular toxicities such as thromboembolic events and hemorrhage, which require imaging for early detection.
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