Key result
The transdiaphragmatic pressure gradient is an important contributor to gastroesophageal reflux disease, even with an intact esophagogastric barrier in obesity and pulmonary diseases.
This review highlights the transdiaphragmatic pressure gradient as a significant pathophysiological contributor to GERD, especially in obese patients and those with pulmonary diseases.
Gastroesophageal reflux disease (GERD) is the most common disease of the upper gastrointestinal tract in the Western world. GERD pathophysiology is multifactorial. Different mechanisms may contribute to GERD including an increase in the transdiaphragmatic pressure gradient (TPG). The pathophysiology of GERD linked to TPG is not entirely understood. This review shows that TPG is an important contributor to GERD even when an intact esophagogastric barrier is present in the setting of obesity and pulmonary diseases.
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Grande et al. (2018) conducted a review in Gastroesophageal reflux disease (GERD). Transdiaphragmatic pressure gradient (TPG) was evaluated. The transdiaphragmatic pressure gradient is an important contributor to gastroesophageal reflux disease, even with an intact esophagogastric barrier in obesity and pulmonary diseases.
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