Increased collagen synthesis and increased content of type VI collagen in myocardium of tight skin mice

Bashey et al. (1993) studied Excessive collagen accumulation (Tight skin mouse mutant strain). Tight skin mouse (TSK) mutation vs. Normal sex and age matched mice was evaluated on Type VI collagen content in myocardium (2.5-fold greater). Hearts from tight skin mice had 2.5-fold greater type VI collagen content (400 micrograms vs 156 micrograms) and up to twofold greater protein and collagen biosynthesis compared with normal mice.