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Deoxyfrenolicin and nanaomycin A have been synthesized. Key steps in the synthesis include a phthalide annulation reaction to produce a naphthoquinone, a tandem Diels-Alder/retro-Claisen reaction to produce the carbon skeleton, and a stereoselective reduction of a hemiketal.
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Kraus et al. (1987) studied this question.
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