Key result
Drug-induced prolongation of the QT interval is a serious adverse effect that has led to market withdrawals and black box warnings for many medications.
Highlights the clinical and regulatory importance of monitoring for drug-induced QT-interval prolongation, a potentially serious adverse effect.
All drugs have the potential to cause adverse effects. Occasionally, serious adverse effects are not identified in preclinical studies and become apparent only when a drug is in widespread clinical use — a particular problem with adverse events that are rare and result in few symptoms. One example of relevance to clinicians and regulatory agencies is drug-induced prolongation of the QT interval. During the past few years, many drugs have been removed from the market or required to include “black box” warnings on their labels because of the potential for QT-interval prolongation. The list of causative medications is daunting, and . . .
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Liu et al. (2004) conducted an editorial in Drug-induced QT-interval prolongation. Drugs causing QT-interval prolongation was evaluated. Drug-induced prolongation of the QT interval is a serious adverse effect that has led to market withdrawals and black box warnings for many medications.
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