Asymmetric Total Synthesis of the Epoxykinamycin FL‐120 B′

Turn up the heat: The synthesis of the title compound was achieved and a route to epoxide-containing diazobenzofluorenes, which could potentially serve as monomers to the dimeric lomaiviticins, was established. Key steps to construct the FL-120B′ core structure include Sharpless asymmetric epoxidation, Stille coupling, and intramolecular Friedel–Crafts acylation of atropisomeric carboxylic acids at elevated temperatures.