Key result
Physical training for 1.5-4 months improved work load capacity in 7 of 9 schizophrenic patients and decreased heart rate and blood lactate, though effects were less consistent with chlorpromazine.
Why the study?
Does physical training improve circulatory parameters during exercise in schizophrenic patients treated with or without chlorpromazine?
Does physical training improve circulatory parameters during exercise in schizophrenic patients treated with or without chlorpromazine?
Physical training can improve circulatory and physiological responses to exercise in schizophrenic patients, though high-dose chlorpromazine may attenuate some of these training effects.
May improve exercise capacity in schizophrenia; hypothesis-generating and requires randomized confirmation before practice change.
Abstract 1. Circulatory studies were performed on four schizophrenics (mean age 27 years) not treated with chlorpromazine and on five (mean age 30 years) treated with large doses of this drug (1800–3600 mg/day), before and after 1.5–4 months of physical training. 2. The physical training consisted of strenuous exercise on a bicycle ergometer for three 6‐minute periods five times a week. 3. After training, all the patients, except two, could cycle with a larger work load for 6–10 minutes. 4. In the drug‐free patients the heart rate and arterial blood lactate decreased with training. This training effect was less consistent in the patients treated with chlorpromazine. 5. The stroke volume was small in relation to the heart volume before training. It tended to become normal in five of eight patients after training. 6. In the patients treated with chlorpromazine, the blood noradrenaline level was high during exercise, and fell in all the patients, except one, after training. In the drug‐free patients, this level was not as high, and there was a further decrease with training in all four patients.
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Carlsson et al. (1968) studied Schizophrenia (n=9). Physical training vs. Before training (baseline) was evaluated on Circulatory parameters (heart rate, arterial blood lactate, stroke volume, blood noradrenaline). Physical training for 1.5-4 months improved work load capacity in 7 of 9 schizophrenic patients and decreased heart rate and blood lactate, though effects were less consistent with chlorpromazine.
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