Chemical synthesis study demonstrates room-temperature amination of aryl chlorides using amides, indicating an efficient, mild catalytic route for carbon-nitrogen bond formation.
We report herein that amides are excellent N-sources in the NHC-Pd(II)-Im complex 1 catalyzed amination of aryl chlorides. In the presence of KO(t)Bu, various aryl chlorides and amides can react smoothly to give the corresponding aminated products in moderate to almost quantitative yields at room temperature within 6 h.
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Chen et al. (2012) studied this question.
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