Copper Nanoparticles Supported on Agarose as a Bioorganic and Degradable Polymer for Multicomponent Click Synthesis of 1,2,3-Triazoles under Low Copper Loading in Water

Agarose-supported copper nanoparticles (CuNPs@agarose) were prepared by immobilization of copper bromide on agarose followed by in situ chemical reduction. The new material was characterized by SEM, EDX, TEM, TGA, XRD, nitrogen adsorption–desorption, and solid UV–vis analysis. The catalytic activity of CuNPs@agarose was assessed in the three component click synthesis of 1,2,3-triazoles in water under low catalyst loading and mild reaction conditions. The easy synthesis and air-stable catalyst was recycled for five runs with small drops in catalytic activity.