Summary A case of probable transplacental metastasis of malignant melanoma from mother to fetus is described. At 2 months of age the infant displayed soft tissue tumors and pulmonary lesions, metastasization of malignant melanoma having occurred shortly before delivery in the mother. The lesions in the infant were thought to be metastasis. These lesions disappeared within a few weeks and on examination at 2 years the child appeared healthy. Observations made in this case and three similar ones in the literature suggest that the induction of immunological tolerance during gestation may play a role in the prognosis of tumor disease in the infants.
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B Cavell (1963) studied this question.
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