A metal-, toxic chloride reagent-free activating strategy of various phosphates has been developed. This method enables the facile synthesis of functional phosphates such as alkyl phosphates, aza phosphates, thiophosphate, and mixed diaryl phosphates. A transient phosphorylpyridin-1-ium species in situ generated from phosphates with Tf 2 O/pyridine readily undergoes a substitution reaction with diverse nucleophiles to form versatile phosphate compounds.
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Huang et al. (2018) studied this question.
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