Treatment of biopsy proved conjunctival intraepithelial neoplasia with topical interferon alfa-2b

Treatment of biopsy proved conjunctival intraepithelial neoplasia with topical interferon alfa-2bConjunctival intraepithelial neoplasia (CIN) is the most common conjunctival malignancy in the United States.It occurs in exposed areas of the bulbar conjunctiva with frequent involvement of the adjacent corneal epithelium.Recent studies 1 have noted a recurrence rate of about 50% when there is pathological evidence of residual tumour in the surgical margin and a 5-33% recurrence rate with clear margins.2 We describe two cases of primary CIN successfully treated with topical INFa-2b.This chart review was conducted with a waiver from the Ochsner Clinic Foundation's institutional review board, and conforms to HIPPA regulations.