Key result
Prestorage leukocyte depletion of blood products is discussed regarding its necessity for preventing refractoriness and HLA-alloimmunization in patients with aplastic thrombocytopenia.
Why the study?
Does prestorage leukocyte depletion prevent refractoriness to platelet transfusion in patients with aplastic thrombocytopenia?
Does prestorage leukocyte depletion prevent refractoriness to platelet transfusion in patients with aplastic thrombocytopenia?
This letter discusses whether prestorage leukocyte depletion is strictly necessary to prevent refractoriness to platelet transfusions.
Novotny et al' described the results of prestorage leukocyte depletion of blood products on the occurrence of refractoriness and development of HLA-antibodies in patients with aplastic thrombocytopenia.The reason for filtration of fresh blood is mainly derived from experiments in animals in which refractoriness and HLA-alloimmunization occurred more frequently when blood products were transfused that were leukocyte-depleted after a period of tora age.''^This was explained by the passage of leukocyte fragments, which arise during storage, through the filter.It is also supposed that, in humans, these fragments are so immunogenic that they give rise to HLAimmunization.
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Wolf et al. (1995) conducted a letter in Aplastic thrombocytopenia. Prestorage leukocyte depletion of blood products was evaluated on Occurrence of refractoriness and development of HLA-antibodies. Prestorage leukocyte depletion of blood products is discussed regarding its necessity for preventing refractoriness and HLA-alloimmunization in patients with aplastic thrombocytopenia.
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