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Alkylphosphonic anhydrides such as (1) are recommended as condensation reagents for peptide synthesis. One advantage of (1) over dicyclohexylcarbodiimide (DCC) is that no sparingly soluble secondary products are formed. With regard to yield and degree of racemization, the new method is just as good as improved DCC techniques, and in some cases superior.
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Wissmann et al. (1980) studied this question.
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