Key result
Dofetilide abolished the action potential duration shortening effect of ischemia but did not alter the cardioprotective effect of preconditioning on infarct size.
Why the study?
Does dofetilide abolish the cardioprotective effect of ischemic preconditioning in a canine model?
Population
Anesthetized dogs subjected to coronary occlusion
Comparison
Dofetilide with or without ischemic… vs Nonpreconditioned hearts, and preconditioned…
Design
Preclinical
Follow-up
60-min coronary occlusion
Authors
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Dissociates APD shortening from preconditioning protection in canines; leaves open mechanistic relevance to human ischemia.
Does dofetilide abolish the cardioprotective effect of ischemic preconditioning in a canine model?
The cardioprotective effect of ischemic preconditioning is independent of action potential duration shortening, as dofetilide abolishes APD shortening but not infarct size reduction.
Grover et al. (1996) studied Myocardial ischemia. Dofetilide vs. Nonpreconditioned hearts / sham was evaluated on Infarct size expressed as a percentage of the area at risk. Dofetilide abolished the action potential duration shortening effect of ischemia but did not alter the cardioprotective effect of preconditioning on infarct size.
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