A change for the better: An efficient method for the identification of mutant methionyl-tRNA synthetases (MetRS) has been developed that enables global incorporation of noncanonical amino acids into recombinant proteins. By using the method, an MetRS variant has been identified that enables near-quantitative replacement of methionine by 6,6,6-trifluoronorleucine (see scheme).
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Yoo et al. (2007) studied this question.
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