Achalasia is an esophageal motility disorder marked by neuronal degeneration within the myenteric plexus, leading to impaired lower esophageal relaxation and swallowing dysfunction. Despite a detailed understanding of its features, the disease's cause remains unknown. Similarly, multiple sclerosis (MS) is an inflammatory demyelinating condition of uncertain cause. Autoimmunity has been suggested as a potential cause of both disorders, yet instances documenting their co-occurrence are rare. We report a case of achalasia diagnosed in a young woman during hospitalization for an apparent MS flare.
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Graham et al. (2025) studied this question.
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