In rat pancreatic islets, the glucagon-producing A-cells also contain a GIP-like material as revealed by the peroxidase-antiperoxidase immunocytochemical technique. Control studies showed that this dual staining was not due to the cross-reactivity of anti-GIP with glucagon. It is concluded either that the A-cells synthesize a GIP-like peptide or that it is taken up from the circulation.
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Smith et al. (1977) studied this question.
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