Total Synthesis of Natural α‐Tocopherol (−)‐(S)‐2‐Methyl‐γ‐butyrolactone (2) represents a versatile chiral C5‐synthon. It serves as key intermediate in one of the syntheses of certain isoprenoid derivatives such as (R)‐dihydrocitronellol, (3R, 7R)‐hexahydrofarnesol and vitamin E of natural configurations. Their syntheses are described in detail.
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Reinhard Zell (1979) studied this question.
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