SUMMARY The pathogenesis of disease caused by 2 strains (219 and Largo) of Newcastle disease virus (ndv) was studied in chickens of various ages. A peracute, systemic, febrile, fatal disease developed after intranasal inoculation of either strain. Strain 219 caused more extensive signs and lesions in the nervous system; strain Largo involved the respiratory tract more extensively. Lesions resulted from diffuse necrosis of the reticuloendothelial system, focal necrosis of visceral organs (heart, brain, lungs, and liver), and lysis of erythrocytes. The virions could not be distinguished ultrastructurally from those of established strains of ndv.
No takes yet. Share an insight, caveat, or question.
Cheville et al. (1972) studied this question.