ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants

Masato Hatta; Gloria P. Larson; Yasuko Hatta; Wei Wang; Nannan Jiang; Yujin Jung; Li Wang; Xiaoyu Fan; Brenda M. Calderon; Gaston Bonenfant; Xudong Lin; Chenchen Feng; Dan Cui; Ginger Atteberry; Michael Currier; John Steel; David E. Wentworth; Bin Zhou

doi:10.3201/eid3108.241844

Key Points

To assess the receptor-binding ability and infectivity of multiple SARS-CoV-2 lineages using ACE2 proteins across a broad range of animal species.
Tested 6 representative SARS-CoV-2 lineages for receptor-binding activity and viral infectivity.
Utilized cell lines expressing angiotensin-converting enzyme 2 (ACE2) orthologs from 54 distinct animal species.
All 6 tested SARS-CoV-2 lineages demonstrated infectivity across a broad spectrum of animal species.
Identified multiple susceptible animal species that may serve as intermediate hosts or natural viral reservoirs.

Implication

In vitro study reveals broad ACE2 infectivity across 54 animal species by six SARS-CoV-2 variants, highlighting potential intermediate hosts and reservoirs.

Abstract

We analyzed the receptor-binding activity and infectivity of 6 representative SARS-CoV-2 lineages in cell lines expressing angiotensin-converting enzyme 2 proteins from 54 different animal species. All viruses demonstrated infectivity in a broad range of species. Susceptible animal species could serve as natural reservoirs or intermediate hosts for SARS-CoV-2.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Hatta et al. (2025) studied this question.

synapsesocial.com/papers/6a9fb987d15c5dee7bbab6a9 https://doi.org/10.3201/eid3108.241844

View Full Paper

Ask AI

Bookmark

Share

ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants

Key Points

Implication

Abstract

Discussion

Cite This Study

ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading