Key result
Patients with left-sided Wolff-Parkinson-White syndrome had a significantly greater azimuth of the ventricular gradient, and those with right-sided syndrome had a significantly greater elevation compared to normal subjects.
Why the study?
Does the spatial ventricular gradient differ between patients with Wolff-Parkinson-White syndrome and normal subjects?
Cross-Sectional (n=656)
Does the spatial ventricular gradient differ between patients with Wolff-Parkinson-White syndrome and normal subjects?
Spatial ventricular gradient parameters from vectorcardiograms can help evaluate repolarization abnormalities and identify the site of accessory pathways in WPW syndrome.
May aid repolarization assessment via vectorcardiography in WPW; leaves open prospective validation for accessory pathway localization.
We investigated the use of the spatial ventricular gradient (VG) from vectorcardiogram (VCG) to determine whether significant repolarization differences were present in patients with WPW syndrome compared with normal subjects and also examined which VG parameter (i.e., elevation, azimuth, and magnitude) reflected the differences in repolarization properties during preexcitation. VG was calculated in 49 patients of Wolff-Parkinson-White (WPW) syndrome (group A: left-sided accessory pathway, n=29; group B: right-sided, n=20). Group N consisted of 607 normal subjects. In group A, the azimuth of VG was significantly (p<0.01) greater than in groups B and N. In group B, the elevation of VG was significantly (p<0.01) greater than in groups A and N. There were no significant differences in the magnitude of VG among groups. QRS duration was significantly (p<0.01) related with the elevation of VG in group B. These findings suggested that VG is useful for spatial evaluation of repolarization abnormalities during preexcitation, which are related to the site of the accessory pathway.(Internal Medicine 34: 738-743, 1995)
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Sawada et al. (1995) conducted a cross-sectional in Wolff-Parkinson-White (WPW) syndrome (n=656). Wolff-Parkinson-White syndrome (preexcitation) vs. Normal subjects was evaluated on Spatial ventricular gradient (azimuth and elevation) (p=<0.01). Patients with left-sided Wolff-Parkinson-White syndrome had a significantly greater azimuth of the ventricular gradient, and those with right-sided syndrome had a significantly greater elevation compared to normal subjects.
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