Synthesis and anticonvulsant activity of 3‐alkyl‐3,4‐dihydro‐2(1H)‐quinazolinones

Previously we reported the potent anticonvulsant activity of 3‐dimethylamino‐3,4‐dihydro‐2(1H)‐quinazolinone. In this report, a series of 3‐alkyl‐3,4‐dihydro‐2(1H)‐quinazolinones was synthesized in three steps from isatoic anhydrides or an anthranilic acid. Structure/activity investigations revealed optimal activity for the 3‐isopropyl and 3‐cyciohexyl analogs. These compounds were effective against seizures induced by maximal electroshock.