Ninety-nine patients with chronic persistent hepatitis were followed up in a prospective study for an average of 6.7 years. Fifty-six patients had positive HBV markers; 29 of these patients had persistent HBs antigenemia, and 4 had persistent HBe antigenemia. No patient developed chronic active hepatitis or cirrhosis of the liver. It can be concluded that chronic persistent hepatitis is a benign non-progressive disease that does not require therapy.
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Vucelić et al. (1988) studied this question.
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