What question did this study set out to answer?

To comprehensively evaluate the genomic characteristics, functional probiotic potential, and safety profile of the marine bacterium Paraliobacillus zengyii CGMCC1.16464.

May 7, 2025Marine DrugsOpen Access

Whole-Genome Sequence Analysis, Probiotic Potential, and Safety Assessment of the Marine Bacterium Paraliobacillus zengyii CGMCC1.16464

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Authors

QFQianjin FanNankai University HHHaoyue HuangfuNankai University LCLan ChenSun Yat-sen University

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Implication

Preclinical evaluation reveals safety and functional probiotic traits in Paraliobacillus zengyii, indicating its potential as a novel marine-derived antiviral probiotic candidate.

Key Points

To comprehensively evaluate the genomic characteristics, functional probiotic potential, and safety profile of the marine bacterium Paraliobacillus zengyii CGMCC1.16464.
Analyzed the whole genome to characterize metabolic pathways, antimicrobial and antiviral gene clusters, and antibiotic resistance profiles.
Assessed in vitro acid and bile salt tolerance, along with hemolytic and gelatinase activities.
Conducted an in vivo acute oral toxicity test in mice administered low, medium, or high doses to monitor body weight, organ indices, and tissue pathology.
Genome annotation identified pathways encoding ectoine, type III polyketide synthases, and lasso peptides, as well as intrinsic, non-plasmid-mediated polymyxin resistance.
In vitro tests confirmed survivability in acidic and bile salt environments with an absence of hemolytic or gelatinase toxicity.
Mouse safety assays showed no adverse impacts on body weight, organ index, or tissue morphology across all tested dose tiers.

Cite This Study

Fan et al. (2025) studied this question.

synapsesocial.com/papers/6a9fbf633a35f4a2c890dc12 https://doi.org/10.3390/md23050202

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Implication

Preclinical evaluation reveals safety and functional probiotic traits in Paraliobacillus zengyii, indicating its potential as a novel marine-derived antiviral probiotic candidate.

Whole-Genome Sequence Analysis, Probiotic Potential, and Safety Assessment of the Marine Bacterium Paraliobacillus zengyii CGMCC1.16464

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Key Points

Cite This Study

Whole-Genome Sequence Analysis, Probiotic Potential, and Safety Assessment of the Marine Bacterium Paraliobacillus zengyii CGMCC1.16464

Discussion

Member takes

Implication

Key Points

Cite This Study

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