Maintenance Dose and Toxicity of Digitoxin

Article1 June 1951MAINTENANCE DOSE AND TOXICITY OF DIGITOXINR. WAYNE MOODY, M.D., F.A.C.P.R. WAYNE MOODY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-6-1349 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe availability of crystalline and weighable forms of digitalis has been a great step forward in the treatment of cardiac disease simply because dosage can now be determined with absolute accuracy. With this fact in mind, the majority of the patients in the Colorado General Hospital Outpatient Heart Clinic were placed on digitoxin over two years ago and have been kept on this drug from that time until the present. Digitoxin was chosen because its oral and intravenous dosage is essentially the same. Whether this advantage outweighs its disadvantages, particularly its long period of excretion, remains to be seen.It...Bibliography1. Therapeutic conference: the treatment of heart failure, Bull. Johns Hopkins Hosp. 71: 411-429, 1947. Google Scholar2. Dick P: Relative values of digitaline preparations in heart failure with auricular fibrillation, Am. Heart J. 10: 122, 1948. CrossrefGoogle Scholar3. GoldCattellModellKwitKramerZahm HMWNMW: Clinical studies on digitoxin (Digitaline Nativelle), J. Pharmacol. and Exper. Therap. 82: 187-194, 1944. Google Scholar4. Vanderveer J: The choice and method of administration of digitalis glycoside preparations, M. Clin. North America 30: 1263-1274, 1946. CrossrefMedlineGoogle Scholar5. EvansDickEvans WPB: Rapid digitalization, Am. Heart Jr. 10: 103, 1948. Google Scholar6. De Graff A: Clinical comparison of the cardiac glycosides, New York State J. Med. 46: 1803-1809, 1946. MedlineGoogle Scholar7. Master A: Digitoxin intoxication, J. A. M. A. 137: 531-534, 1948. CrossrefMedlineGoogle Scholar8. Flaxman N: Digitoxin poisoning, Am. J. M. Sc. 216: 179-182, 1948. CrossrefMedlineGoogle Scholar9. BattermanDe Graff RA: Comparative study on the use of purified digitalis glycosides, digoxin, digitoxin, and lanatoside C, for the management of ambulatory patients with congestive heart failure, Am. Heart J. 34: 663-673, 1947. CrossrefMedlineGoogle Scholar10. MareshFarah GA: Toxicity ratios of some cardiac glycosides as influenced by experimental time, Federation Proc. 5: 191, 1946. MedlineGoogle Scholar11. EichnaTaube LH: A comparison of the actions of four cardiac glycosides on a patient with congestive heart failure, Am. Heart J. 26: 631-643, 1943. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, Colorado*Received for publication November 18, 1949. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNon-cardiac symptoms of digitalis intoxicationRecognition and therapy of digitalis toxicityRecognition and therapy of digitalis toxicityAdams-Stokes syndrome due to sinoatrial blockEffect of digitalis on conduction of the heartDeliberate Digitalis Intoxication A Comparison of the Toxic Effects of Four Glycoside PreparationsG. CHURCH, M.B., F.R.F.P.S., L. SCHAMROTH, M.B., M.R.C.P., NEIL L. SCHWARTZ, M.B., M.R.C.P., HENRY J. L. MARRIOTT, M.A., B.M.The toxicology of digitalis∗DIGITALIS INTOXICATION: A CLINICAL REPORT OF 148 CASES*DIETEGEN VON CAPELLER, M.D., G. DANIEL COPELAND, M.D., THOMAS N. STERN, M.D.THE ASCENDANCY OF DIGITOXIN AND RENAISSANCE OF GITALINH. J. L. MARRIOTTDigitalis Poisoning and Its Treatment 1 June 1951Volume 34, Issue 6Page: 1349-1357KeywordsDrugsExcretionHeartHeart diseasesOutpatient clinicsToxicity ePublished: 1 December 2008 Issue Published: 1 June 1951 PDF downloadLoading ...