Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1959American Journal of Physiology-Legacy Content

Nature of the thrombin-inhibiting effect of incubated fibrinogen

View Full Paper
Ask AI
Bookmark
Share

Key result

The anticoagulant fraction of incubated fibrinogen competitively inhibits the action of thrombin on fibrinogen, an effect abolished by heating above 55°C and modulated by pH and divalent cations.

Population

In vitro biochemical model studying the anticoagulant fraction of incubated fibrinogen, thrombin, and…

Design

Preclinical

Authors

DTD. C. TriantaphyllopoulosAmerican Red Cross

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for fibrinogen-derived thrombin inhibitors; requires human validation before clinical consideration.

Structured PICO

P
Population
In vitro biochemical model studying the anticoagulant fraction of incubated fibrinogen (AFIF), thrombin, and fibrinogen
I
Intervention
Exposure to various physical and chemical factors including heating (46°C to 55°C), pH variations, calcium and magnesium (up to 10 mm), and protamine
O
Outcome
Thrombin-inhibiting activity and thrombin time of fibrinogen and plasmasurrogate

The anticoagulant fraction of incubated fibrinogen competitively inhibits thrombin action on fibrinogen, with properties distinct from heparin and sensitivity to heat and pH.

Cite This Study

D. C. Triantaphyllopoulos (1959) studied this question. Anticoagulant fraction of incubated fibrinogen (AFIF) was evaluated on Thrombin-inhibiting activity. The anticoagulant fraction of incubated fibrinogen competitively inhibits the action of thrombin on fibrinogen, an effect abolished by heating above 55°C and modulated by pH and divalent cations.

synapsesocial.com/papers/6a9fc1d93579a0ffc99c97eahttps://doi.org/10.1152/ajplegacy.1959.197.3.575
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A kinetic study on the effects of anticoagulants on the interaction of fibrinogen and thrombin1987 · 5 citations
  2. 2Quantification of the effects of thrombin activatable fibrinolysis inhibitor and α2-antiplasmin on fibrinolysis in normal human plasma2006 · 16 citations
  3. 3Argatroban enhances fibrinolysis by differential inhibition of thrombin-mediated activation of thrombin activatable fibrinolysis inhibitor and factor XIII2008 · 18 citations
  4. 4Examination of irreversible platelet-fibrinogen interactions1985 · 49 citations
  5. 5Enhancement of fibrinolytic potential in vitro by anticoagulant drugs targeting activated factor X, but not by those inhibiting thrombin or tissue factor2003 · 32 citations