Elevated plasma protein C levels correlate with the presence of fatty liver (NASH and NAFLD)

The clinical implications of non-alcoholic fatty liver disease (NAFLD) are derived mostly from its common occurrence in the general population and the potential of the condition to progress to fibrosis and cirrhosis.1 Markers that help in making an early diagnosis and treatment are warranted. Protein C is a vitamin K dependent glycoprotein that functions as a circulating anticoagulant through proteolytic cleavage and inactivation of the coagulation factors Va and VIIIa.2 Whether or not protein C levels increase in patients with NAFLDs has not been assessed. We measured protein C …