Key result
Concomitant overdose of a benzodiazepine with multiple serotonergic agents resulted in a shortened and less severe course of serotonin syndrome in an 18-year-old male.
Case Report (n=1)
No
Concomitant overdose of a benzodiazepine with serotonergic agents may lessen the severity of serotonin syndrome, but prompt recognition and treatment remain essential.
Benzodiazepine co-ingestion may lessen serotonin syndrome severity; hypothesis-generating case report requiring prospective validation before any practice consideration.
This case report discusses the history and management of a schizophrenic patient, a 18-year-old man, who had taken a massive overdose of clonazepam, abilify, depakote, zoloft and seroquel altogether.After discontinuation of these drugs and administration of cyproheptadine with IV fluids, he became hemodynamically stable.This case suggests that serotonin syndrome should be recognized promptly and complications need to be treated appropriately.Serotonin syndrome should be diagnosed surely to ensure the prompt initiation of the treatment including discontinuation of the precipitating drugs because the disease occasionally progresses rapidly to fatal condition.In addition, both the onset and resolution of symptoms are faster in serotonin syndrome.
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Schrapp (2014) conducted a case report in Serotonin Syndrome (n=1). Concomitant ingestion of benzodiazepine with serotonergic agents was evaluated on Clinical presentation and resolution of serotonin syndrome. Concomitant overdose of a benzodiazepine with multiple serotonergic agents resulted in a shortened and less severe course of serotonin syndrome in an 18-year-old male.
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