Key result
All five vasodilators decreased systemic blood pressure and heart rate while increasing right atrial pressure, but SK&F 24260 uniquely produced a marked increase in venous return and cardiac output.
In a canine model, SK&F 24260 acts predominantly on blood vessels to increase venous return, whereas D 600, diltiazem, dilazep, and trimetazidine exert more prominent negative inotropic effects on the heart.
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Highlights mechanistic differences among vasodilators in canines; hypothesis-generating and should not yet influence practice.
Imai et al. (1977) studied Healthy (animal model) (n=20). SK&F 24260, D 600, diltiazem, dilazep, and trimetazidine vs. Baseline was evaluated on Cardiohemodynamic parameters including systemic blood pressure, cardiac output, venous return, right atrial pressure, and heart rate. All five vasodilators decreased systemic blood pressure and heart rate while increasing right atrial pressure, but SK&F 24260 uniquely produced a marked increase in venous return and cardiac output.
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