Key result
A 12-week course of intravenous antibiotics and anticoagulation with apixaban resulted in complete recovery and resolution of the apical mural thrombus in a patient with S. aureus myocarditis.
Case Report (n=1)
Staphylococcus aureus myocarditis complicated by a left ventricular apical thrombus can be successfully managed with prolonged intravenous antibiotics and anticoagulation, with resolution confirmed by cardiac magnetic resonance imaging.
Alerts to S. aureus myocarditis with apical thrombus despite preserved EF in immunocompromised septic shock; leaves open optimal imaging and management strategies.
Staphylococcus aureusmyocarditis is a rare diagnosis with a high mortality rate, usually seen in people who are immunocompromised. Here, we report a case of a 44-year-old man on methotrexate for rheumatoid arthritis who presented in septic shock and was diagnosed withstaphylococcus aureusmyocarditis. The myocarditis was associated with a left ventricular apical thrombus, with normal systolic function. The myocarditis and associated thrombus were characterised on transthoracic echocardiogram and subsequently on cardiac magnetic resonance imaging. Cardiac magnetic resonance (CMR) imaging showed oedema in the endomyocardium, consistent with acute myocarditis, associated with an apical mural thrombus. Repeat CMR 3 weeks following discharge from hospital showed marked improvement in endomyocardial oedema and complete resolution of the apical mural thrombus. He was treated with a 12-week course of antibiotics and anticoagulated with apixaban. The patient was successfully managed with intravenous antibiotics and anticoagulation with complete recovery.
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McGee et al. (2018) conducted a case report in Staphylococcus aureus myocarditis with associated left ventricular apical thrombus (n=1). Intravenous antibiotics and apixaban was evaluated on Clinical recovery and resolution of thrombus. A 12-week course of intravenous antibiotics and anticoagulation with apixaban resulted in complete recovery and resolution of the apical mural thrombus in a patient with S. aureus myocarditis.
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