The Value of the C-Reactive Protein Determination in Coronary Artery Disease

Article1 January 1957THE VALUE OF THE C-REACTIVE PROTEIN DETERMINATION IN CORONARY ARTERY DISEASEMICHAEL C. KOZONIS, M.D., IRFAN GUREVIN, M.D.MICHAEL C. KOZONIS, M.D.Search for more papers by this author, IRFAN GUREVIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-1-79 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe C-reactive protein test is a highly sensitive test for the presence of acute inflammation. The capsule of the pneumococcus bacterium contains a specific polysaccharide called C polysaccharide, which behaves as a specific antigen. If one studies the sera of patients with pneumonitis of pneumococcal origin, an antibody for this C polysaccharide can be demonstrated. The antibody is a protein and has been named C-reactive protein.In 1930 Tillet and Francis1demonstrated for the first time the presence of the above substance in a patient with pneumococcal pneumonitis. Later they observed that this substance was found only in sera of...Bibliography1. TilletFrancis WST: Serological reaction in pneumonia with a non-protein somatic fraction of pneumococcus, J. Exper. Med. 52: 561 (Oct. 1) 1930. CrossrefMedlineGoogle Scholar2. MacLeodAvery CMOT: The occurrence during acute infections of a protein not normally present in the blood. II. Isolation and properties of the reactive protein, J. Exper. Med. 73: 183 (Feb. 1) 1941. CrossrefMedlineGoogle Scholar3. Wood HF: The relationship between the acute phase, response and antibody production in the rabbit. 1. Correlation between the early appearance of CX-reactive protein and subsequent antibody production, J. Exper. Med. 98: 311 (Oct. 1) 1953. CrossrefMedlineGoogle Scholar4. McCarty M: The occurrence during acute infection of a protein not normally present in the blood. IV. Crystallization of the C. Reactive Protein, J. Exper. Med. 85: 491 (May 1) 1947. CrossrefMedlineGoogle Scholar5. McEwer C: Recent advances in diagnosis and treatment of rheumatic fever, M. Clin. North America 39: 353 (Mar.) 1955. CrossrefGoogle Scholar6. WoodMcCarty HFM: Laboratory aids in the diagnosis of rheumatic fever and in evaluation of disease activity, Am. J. Med. 17: 768 (Dec.) 1954. CrossrefMedlineGoogle Scholar7. ShackmanHefferKroop NHETIG: The C-reactive protein determination as a measure of rheumatic activity, Am. Heart J. 48: 599 (Oct.) 1954. CrossrefMedlineGoogle Scholar8. KroopShackman IGNH: Level of C-reactive protein as a measure of acute myocardial infarction, Proc. Soc. Exper. Biol. and Med. 86: 95 (May) 1954. CrossrefMedlineGoogle Scholar9. SpruntHale DHWM: A method of evaluating cancer tests, Proc. Am. Assoc. Cancer Res. 2: 47-48 (Apr.) 1955. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 20, 1956.Requests for reprints should be addressed to Michael C. Kozonis, M.D., 1301 Pontiac State Bank Building, Pontiac, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byC-Reactive Protein: Clinical and Epidemiological PerspectivesÜbersichtSerum levels of acute phase and cardiac proteins after myocardial infarction, surgery, and infection.Das Verhalten des C-Reaktiven Protein beim MyokardinfarktDie Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und HerzinfarktThe Acute Phase Protein Reaction II. Clinical Application 1 January 1957Volume 46, Issue 1Page: 79-85KeywordsAntigensC-reactive proteinsElectrocardiographyInflammationNecrosisPneumococcusPneumonitisPolysaccharidesProteinsStable coronary artery disease ePublished: 1 December 2008 Issue Published: 1 January 1957 PDF downloadLoading ...